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<div style="margin:0 0 10px 0;"><b>Gesendet:</b> Dienstag, 16. Mai 2023 um 10:36 Uhr<br/>
<b>Von:</b> "dzg evol" <dzg.evol@gmail.com><br/>
<b>An:</b> "dzg evol" <dzg.evol@gmail.com><br/>
<b>Betreff:</b> [dzg-evol] Vienna, Austria: Post-doc positions - polygenic adaptation</div>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Postdoc positions are available within the </span><span style="color: black;"><a href="https://www.vetmeduni.ac.at/sfb-polygenic-adaptation" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Special Research Program (SFB)</span></b></a></span><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> "Polygenic adaptation: from single selected loci to the infinitesimal model" in Vienna, Austria</span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">. Vienna is on top of the world's most liveable cities and home to one of the largest communities of evolutionary research in Europe (<a href="http://www.evolVienna.at" style="color: blue;" target="_blank">www.evolVienna.at</a>).</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The SFB program is funded by the Austrian Science Fund (FWF) and brings together eight research groups at four institutions in and around Vienna with the common goal of elucidating the evolutionary genetics of adaptation of complex phenotypes: </span><span style="text-indent: 36.0pt;color: black;"><a href="https://www.vetmeduni.ac.at/en/population-genetics/research/barghi-lab/group-leader" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Neda Barghi</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">, </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://www.vetmeduni.ac.at/en/population-genetics/research/kofler-lab" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Robert Kofler</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">, </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://www.vetmeduni.ac.at/en/population-genetics/research/schloetterer-lab" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Christian Schlötterer</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> (Vetmeduni); </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://www.mabs.at/team/" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Joachim Hermisson</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">, </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://www.mabs.at/team/" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Himani Sachdeva</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> (Univ. of Vienna); </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://www.oeaw.ac.at/gmi/research/research-groups/magnus-nordborg/" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Magnus Nordborg</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">, </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://www.oeaw.ac.at/gmi/research/research-groups/kelly-swarts" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Kelly Swarts</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> (Gregor Mendel Institute); </span></b><span style="text-indent: 36.0pt;color: black;"><a href="https://bartongroup.pages.ist.ac.at/people/group-leader/" style="color: blue;" target="_blank"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;">Nick Barton</span></b></a></span><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> (ISTA)</span></b><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;">. For young scientists, this cluster offers a unique environment for interaction and personal growth.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="color: black;font-family: Arial , sans-serif;text-indent: 36.0pt;">The SFB aims to develop a framework for understanding polygenic adaptation and to establish new standards for the analysis of adaptive polygenic traits in GWAS and experimental evolution studies. We will combine model-based conceptual work and data-driven approaches from GWAS and experimental evolution to achieve this goal. The models and methods that will be developed integrate population genetic and quantitative genetic approaches to detect, analyze, and interpret genomic patterns of the “architecture of polygenic adaptation”.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">SFB – a collaborative environment for research and learning: </span></b><span style="color: black;font-family: Arial , sans-serif;">The theoretical and empirical projects of the SFB are highly synergistic and the collaborative nature of the SFB will provide an inspiring academic environment and promote curiosity-driven research. The interaction between projects of the SFB is strongly facilitated by a long-standing track record of fruitful interactions among the PIs. The PhD students and postdocs in the SFB will benefit enormously from these</span><span style="color: black;font-family: Arial , sans-serif;"> tight interactions.</span></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="color: black;font-family: Arial , sans-serif;text-indent: 36.0pt;">To ensure a good integration of experiment and theory, researchers have the opportunity to spend some time in a group from the other “camp”. These regular exchanges will improve the mutual understanding of concepts and problems, ensure that the theoretical work is guided by experiments (and vice versa) and will represent a true added value of the SFB. In addition to the formal supervisor, both PhD students and postdocs will have at least one co-advisor with complementary expertise.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Courses: </span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The recruited early-stage researchers in the SFB will have the opportunity to acquire experience beyond their own projects and working groups.</span></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The SFB PIs participate in joint teaching activities and representatives of all institutions are contributing to the Vienna Graduate School of Population Genetics (</span><span style="text-indent: 36.0pt;color: black;"><a href="https://www.popgen-vienna.at/" style="color: blue;" target="_blank"><span style="line-height: 150.0%;font-family: Arial , sans-serif;">www.popgen-vienna.at</span></a></span><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;">). The PhD students will be integrated in the Vienna Graduate School of Population Genetics, which offers a 5-week introductory course that covers subjects as diverse as statistics, population genetics, Drosophila genetics, programming, NGS data analysis (both DNA- and RNA-Seq) and quantitative genetics.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">SFB postdocs will have the opportunity to participate in the teaching in introductory course in their areas of expertise. But at the same time can attend specific modules of the introductory course together with the PhD students. This joint event will have a tremendous impact on team-building and can enable scientists from different host institutions to establish strong ties which can result in research collaborations.</span></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The IST Graduate School offers more advanced courses in evolutionary genetics and bioinformatics (</span><span style="text-indent: 36.0pt;color: black;"><a href="https://phd.pages.ist.ac.at/courses/" style="color: blue;" target="_blank"><span style="line-height: 150.0%;font-family: Arial , sans-serif;">https://phd.pages.ist.ac.at/courses/</span></a></span><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;">), which will be available to students and postdocs in the SFB.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Monthly SFB meetings: </span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">We will have monthly SFB meetings where PhD students and postdocs can present their research. The monthly SFB meetings will provide a platform for early-stage researchers to present the progress of their research and receive helpful and constructive feedback. </span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Journal clubs and seminars: </span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">All SFB members will participate in weekly journal clubs and will benefit from the weekly seminar series at the Vienna Graduate School of Population Genetics and at ISTA, both of which provide opportunities for one-to-one interactions with internationally leading researchers. </span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Conferences: </span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">All early-stage researchers will be encouraged to present their results at national and international conferences and workshops, where they will be able to network with their peers and with more senior researchers. </span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Available infrastructure of research institutions of the SFB: </span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The participating institutions in the SFB provide exceptional training infrastructure. All institutions offer access to excellent computing infrastructure, molecular biology laboratories and electronic access to all relevant journals.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="font-family: Arial , sans-serif;color: black;">OPEN POSITIONS:</span></b></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Three postdoc positions</span></b><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> are available in the groups of <b>Joachim Hermisson, Himani Sachdeva </b>and<b> Magnus Nordborg</b> for 2 years, each (with potential extension). Salary is according to FWF rates for postdocs (€ 4.351,90 before tax). The starting date is January 2024 (with some flexibility). Application is open until positions are filled.</span></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b style="text-indent: 36.0pt;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">Application:</span></b><span style="text-indent: 36.0pt;line-height: 150.0%;font-family: Arial , sans-serif;color: black;"> For informal inquiries and further information, interested candidates are encouraged to contact Joachim Hermisson and Himani Sachdeva (joachim.hermisson[AT]<a href="http://univie.ac.at" target="_blank">univie.ac.at</a>, himani.sachdeva[AT]<a href="http://univie.ac.at" target="_blank">univie.ac.at</a>) or Magnus Nordborg (magnus.nordborg[AT]<a href="http://gmi.oeaw.ac.at" target="_blank">gmi.oeaw.ac.at</a>) before submitting a formal application. In this case, please send a brief statement of interest and CV.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="font-family: Arial , sans-serif;color: black;">Postdoc positions in evolutionary modeling (Univ. of Vienna, AT)</span></b></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The mathematics and biosciences group led by Joachim Hermisson and Himani Sachdeva at the University of Vienna is looking for strong and highly motivated candidates for <b>two postdoc positions in evolutionary modeling</b>.</span></p>
<p style="margin: 0.0cm;text-indent: 36.0pt;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">In recent years, following the massive inflow of data from GWAS, the genetics of complex traits has become one of the main fields of study in evolutionary research. Of particular interest - but so far poorly understood - are the dynamics of such traits during adaptive evolution. How does phenotypic adaptation typically proceed? Under what conditions do we see classic signatures of selective sweeps due to large and rapid changes in allele frequencies in the underlying genes? When does adaptation occur through subtle shifts at many loci, and how could these be detected from footprints in genomic data? What is the role of linkage, and when does selection act on extended haplotypes rather than on individual loci?</span></p>
<p style="margin: 0.0cm;text-indent: 36.0pt;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">In <b>two projects</b>, we want to develop models for the adaptation of complex traits. One project deals with the <b>change in adaptive architectures</b> depending on the number of alleles involved. A particular interest is "oligogenic adaptation", the poorly understood parameter range between "monogenic adaptation" (described by population genetics) and "highly polygenic adaptation" (captured by classical quantitative genetic approaches). The second project focuses on <b>signatures of highly polygenic adaptation</b> involving selection on haplotypes with many small-effect ("infinitesimal") variants, and how selection response is influenced by linkage disequilibrium in the initial population. Both projects aim to understand key phenomena through analytical theory and link to genomic data through computational and statistical modeling.</span></p>
<p style="margin: 0.0cm;text-indent: 36.0pt;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">We are looking for candidates with a strong background in quantitative methods (analytical and computational modeling) in evolutionary research. Programming skills are highly appreciated. Applicants should have completed their PhD in a relevant field at the latest by the start of the position. The working language in the group is English. German skills are not essential.</span></p>
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<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><b><span style="font-family: Arial , sans-serif;color: black;">Postdoc position in genetics of local adaptation (Gregor Mendel Institute, AT)</span></b></p>
<p style="margin: 0.0cm;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">A postdoc position is available in the <b>Nordborg</b> laboratory for someone interested in <b>understanding the genetics of local adaptation</b>. One approach for studying this originates in <b>molecular population genetics</b>, and focuses on identifying loci under selection — leaving the question of how quantitatively important for adaptation these loci are unanswered. Another approach stems from <b>quantitative genetics</b>, and dissects the genetics of traits using genetic mapping — which tells us much about the genetics of the trait(s) measured in the particular environment, but does not directly address adaptation. How do we combine these frameworks?</span></p>
<p style="margin: 0.0cm;text-indent: 36.0pt;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">A related question is how we study traits that are selected to be the same in all environment. The classical approach is a transplantation experiment or common garden experiment, how do we know that the phenotypic variation revealed when organisms are grown in an environment for which they are not adapted is adaptively relevant? It could be cryptic variation revealed by the environmental perturbation.</span></p>
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<p style="margin: 0.0cm;text-indent: 36.0pt;line-height: 150.0%;font-family: "Times New Roman" , serif;"><span style="line-height: 150.0%;font-family: Arial , sans-serif;color: black;">The lab has considerable strength in <b>evolutionary biology</b> and <b>population genetics</b>, in particular in <b>plants</b>, where we have access to large amounts of data from <i>Arabidopsis thaliana</i> and fantastic infrastructure for plant growth and genomics. For more information, please see the lab web pages. We are located at the Gregor Mendel Institute, which is part of the Vienna BioCenter in Vienna’s 3rd District. The campus is English-speaking and hosts 2000 researchers from over 70 countries. We are family-friendly and provide on-campus day care.</span></p>
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<div><span style="color: rgb(34,34,34);">Dr. Julia Hosp</span><br style="color: rgb(34,34,34);"/>
<br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);">Vienna Graduate School of Population Genetics</span><br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);">Coordinator</span><br style="color: rgb(34,34,34);"/>
<br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);"><a href="http://www.popgen-vienna.at" target="_blank">www.popgen-vienna.at</a></span><br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);"><a href="https://twitter.com/PopGenViennaPhD" target="_blank">https://twitter.com/PopGenViennaPhD</a></span><br style="color: rgb(34,34,34);"/>
<br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);">c/o</span><br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);">Institut für Mathematik, Universität Wien</span><br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);">& </span><span style="color: rgb(34,34,34);">Institut für Populationsgenetik, Veterinärmedizinische Universität Wien</span><br style="color: rgb(34,34,34);"/>
<br style="color: rgb(34,34,34);"/>
<span style="color: rgb(34,34,34);">T +43 1 25077 4302</span></div>
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